10-deoxymethynolide desosaminyltransferase EC#: 2.4.1.277; ChemWhat Code: 1377594

Product Name 10-deoxymethynolide desosaminyltransferase
Example Structure Example Structure of 10-deoxymethynolide desosaminyltransferase EC#: 2.4.1.277
Synonyms DesVII, DesVII/DesVIII, glycosyltransferase DesVII, macrolide glycosyltransferase DesVII
EC Number 2.4.1.277
CAS Registry Number
Comments DesVII is the glycosyltransferase responsible for the attachment of dTDP-D-desosamine to 10-deoxymethynolide or narbonolide during the biosynthesis of methymycin, neomethymycin, narbomycin, and pikromycin in the bacterium Streptomyces venezuelae. Activity requires an additional protein partner, DesVIII.
Cofactor
History
Reactions dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide = dTDP + 10-deoxymethymycin.

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