12alpha-hydroxysteroid dehydrogenase EC#: 1.1.1.176; ChemWhat Code: 1373236
| Product Name | 12alpha-hydroxysteroid dehydrogenase |
| Example Structure |  |
| Synonyms | 12alpha-HSDH, 12alpha-hydroxy steroid dehydrogenase, dehydrogenase, 12alpha-hydroxy steroid, NAD+-dependent 12alpha-HSDH, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, NADP+-dependent 12alpha-HSDH, NADP-12alpha-hydroxysteroid dehydrogenase, NADP-dependent 12alpha-hydroxysteroid dehydrogenase |
| EC Number | 1.1.1.176 |
| CAS Registry Number | 61642-40-8 |
| Comments | Catalyses the oxidation of the 12¦Á-hydroxy group of bile acids, both in their free and conjugated form. Also acts on bile alcohols. |
| Cofactor | |
| History | |
| Reactions | 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NADP(+) = 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate + Nadph. |
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