13-deoxydaunorubicin hydroxylase EC#: 1.14.13.181; ChemWhat Code: 1375417
| Product Name | 13-deoxydaunorubicin hydroxylase |
| Example Structure |  |
| Synonyms | DoxA, DoxA monooxygenase |
| EC Number | 1.14.13.181 |
| CAS Registry Number | |
| Comments | The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius show broad substrate specificity for structures based on an anthracycline aglycone, but have a strong preference for 4-methoxy anthracycline intermediates (13-deoxydaunorubicin and 13-dihydrodaunorubicin) over their 4-hydroxy analogues (13-deoxycarminomycin and 13-dihydrocarminomycin), as well as a preference for substrates hydroxylated at the C-13 rather than the C-14 position. |
| Cofactor | |
| History | |
| Reactions | (1) 13-deoxydaunorubicin + Nadph + O(2) = 13-dihydrodaunorubicin + NADP(+) + H(2)O. (2) 13-dihydrodaunorubicin + Nadph + O(2) = daunorubicin + NADP(+) + 2 H(2)O. |
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