| Product Name |
1,4-dihydroxy-2-naphthoate polyprenyltransferase |
| Example Structure |
 |
| Synonyms |
1,4-dihydroxy-2-naphthoate octaprenyltransferase, MenA |
| EC Number |
2.5.1.74 |
| CAS Registry Number |
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| Comments |
This enzyme catalyses a step in the synthesis of menaquinone, in which the prenyl chain synthesized by polyprenyl diphosphate synthase is transferred to 1,4-dihydroxy-2-naphthoate (DHNA). The bacterial enzyme is an inner membrane protein [1], with the C-terminus located in the periplasm [3]. It is highly specific for DHNA but not for a specific length of the prenyl chain [2]. |
| Cofactor |
|
| History |
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| Reactions |
An all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate = a demethylmenaquinol + diphosphate + CO(2). |
