(1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase EC#: 4.2.3.165; ChemWhat Code: 1382762

Product Name (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase
Example Structure Example Structure of (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase EC#: 4.2.3.165
Synonyms STC5
EC Number 4.2.3.165
CAS Registry Number
Comments The original enzyme (STC5) from the fungus?Fusarium fujikuroi?is inactive because of a critically naturally occuring mutation that leads to an asparagine to lysine exchange in the NSE (Asn-Ser-Glu) triad, a highly conserved motif of type I terpene cyclases. Sequence correction by site-directed mutagenesis (K288N) restores activity.
Cofactor
History
Reactions (2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate.

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