(1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase EC#: 4.2.3.165; ChemWhat Code: 1382762
| Product Name | (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase |
| Example Structure |  |
| Synonyms | STC5 |
| EC Number | 4.2.3.165 |
| CAS Registry Number | |
| Comments | The original enzyme (STC5) from the fungus?Fusarium fujikuroi?is inactive because of a critically naturally occuring mutation that leads to an asparagine to lysine exchange in the NSE (Asn-Ser-Glu) triad, a highly conserved motif of type I terpene cyclases. Sequence correction by site-directed mutagenesis (K288N) restores activity. |
| Cofactor | |
| History | |
| Reactions | (2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate. |
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