2-(3-amino-3-carboxypropyl)histidine synthase EC#: 2.5.1.108; ChemWhat Code: 1378046

Product Name 2-(3-amino-3-carboxypropyl)histidine synthase
Example Structure Example Structure of 2-(3-amino-3-carboxypropyl)histidine synthase EC#: 2.5.1.108
Synonyms diphthine synthase, Dph2, DPH4, PhDph2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase
EC Number 2.5.1.108
CAS Registry Number
Comments A [4Fe-4S] enzyme that modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. The enzyme is present in archae and eukaryotes but not in eubacteria. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii. Part of diphthamide biosynthesis.
Cofactor iron-sulfur
History
Reactions L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5′-thioadenosine.

Buy Reagent

No reagent supplier? Send quick inquiry to ChemWhat
Want to be listed here as a reagent supplier? (Paid service) Click here to contact ChemWhat

Approved Manufacturers

Want to be listed as an approved manufacturer (Requires approvement)? Please download and fill out this form and send back to approved-manufacturers@chemwhat.com

Contact Us for Other Help

Contact us for other information or services Click here to contact ChemWhat