AlloH, btrC, BtrC2, DOI synthase, DOIS, KanA, kanC, neoC, tbmA
EC Number
4.2.3.124
CAS Registry Number
Comments
Requires Co2+?[2]. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Requires an NAD+?cofactor, which is transiently reduced during the reaction [1,4]. The enzyme from the bacterium?Bacillus circulans?forms a complex with the glutamine amidotransferase subunit of pyridoxal 5′-phosphate synthase (EC?4.3.3.6), which appears to stabilize the complex [6,7].
