2-haloacid dehalogenase (configuration-inverting) EC#: 3.8.1.10; ChemWhat Code: 1381824
| Product Name | 2-haloacid dehalogenase (configuration-inverting) |
| Example Structure |  |
| Synonyms | 2-HAD, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL DEX 113, DL-2-haloacid dehalogenase, DL-2-haloacid dehalogenase (inversion of configuration), DL-2-haloacid halidohydrolase (inversion of configuration), DL-DEX, DL-DEX 113, DL-DEX Mb, DL-DEXi, L-2-haloacid dehalogenase, L-DEX YL, ps-2-HAD |
| EC Number | 3.8.1.10 |
| CAS Registry Number | |
| Comments | Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2. The enzyme from?Pseudomonas?sp. 113 acts on 2-haloalkanoic acids whose carbon chain lengths are five or less. [See also EC?3.8.1.2, (S)-2-haloacid dehalogenase, EC?3.8.1.9, (R)-2-haloacid dehalogenase and EC?3.8.1.11, 2-haloacid dehalogenase (configuration-retaining)]. |
| Cofactor | |
| History | |
| Reactions | (1) (S)-2-haloacid + H(2)O = (R)-2-hydroxyacid + halide. (2) (R)-2-haloacid + H(2)O = (S)-2-hydroxyacid + halide. |
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