2-hydroxy-3-oxoadipate synthase EC#: 2.2.1.5; ChemWhat Code: 1376702
| Product Name | 2-hydroxy-3-oxoadipate synthase |
| Example Structure |  |
| Synonyms | (R)-HOA synthase, 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), 2-hydroxy-3-oxoadipate synthase, 2-oxoglutarate: glyoxylate carboligase, alpha-ketoglutarate:glyoxylate carboligase, alpha-ketoglutaric-glyoxylic carboligase, carboligase, EC 4.1.3.15, glyoxylate-2-oxoglutarate carboligase, HOA synthase, HOAS, oxoglutarate: glyoxylate carboligase, Rv1248c |
| EC Number | 2.2.1.5 |
| CAS Registry Number | 9054-72-2 |
| Comments | The bacterial enzyme requires thiamine diphosphate. The product decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate. |
| Cofactor | thiamine diphosphate |
| History | |
| Reactions | 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO(2). |
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