| Product Name |
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase |
| Example Structure |
 |
| Synonyms |
2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate-6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, CHMS dehydrogenase, CHMS hydrolase, dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde |
| EC Number |
1.1.1.312 |
| CAS Registry Number |
|
| Comments |
The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity. The enzyme was initially believed to act on 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-cis,cis-muconate [1]. However, later studies showed that the substrate is the hemiacetal form [3], and the product is 2-oxo-2H-pyran-4,6-dicarboxylate [2,4]. |
| Cofactor |
|
| History |
|
| Reactions |
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo- 2H-pyran-4,6-dicarboxylate + Nadph. |
