2-hydroxy-dATP diphosphatase EC#: 3.6.1.56; ChemWhat Code: 1381621
| Product Name | 2-hydroxy-dATP diphosphatase |
| Example Structure |  |
| Synonyms | (2′-deoxy) ribonucleoside 5′-triphosphate pyrophosphohydrolase, hMTH1, MTH1, MTH2, NUDT1 |
| EC Number | 3.6.1.56 |
| CAS Registry Number | |
| Comments | The enzyme hydrolyses oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC?3.6.1.55, 8-oxo-dGTP diphosphatase) [3]. |
| Cofactor | |
| History | |
| Reactions | 2-hydroxy-dATP + H(2)O = 2-hydroxy-dAMP + diphosphate. |
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