| Product Name |
2-hydroxypropyl-CoM lyase |
| Example Structure |
 |
| Synonyms |
coenzyme M-epoxyalkane ligase, Ea-CoMT, EaCoMT, epoxyalkane coenzyme M transferase, epoxyalkane:2-mercaptoethanesulfonate transferase, epoxyalkane:CoM transferase, epoxyalkyl:CoM transferase, epoxypropane:coenzyme M transferase, epoxypropyl:CoM transferase, EtnE, transferase, epoxyalkyl:coenzyme M |
| EC Number |
4.4.1.23 |
| CAS Registry Number |
244301-07-3 |
| Comments |
Requires zinc. Acts on both enantiomers of chiral epoxyalkanes to form the corresponding (R)- and (S)-2-hydroxyalkyl-CoM adducts. The enzyme will function with some other thiols (e.g., 2-sulfanylethanol) as the nucleophile. Uses short-chain epoxyalkanes from C2?(epoxyethane) to C6?(1,2-epoxyhexane). This enzyme forms component I of a four-component enzyme system {comprising EC?4.4.1.23?(2-hydroxypropyl-CoM lyase; component I), EC?1.8.1.5?[2-oxopropyl-CoM reductase (carboxylating); component II], EC?1.1.1.268?[2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC?1.1.1.269?[2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in?Xanthobacter?sp. strain Py2. |
| Cofactor |
Zn2+ |
| History |
|
| Reactions |
(1) (R)-2-hydroxypropyl-CoM = (R)-1,2-epoxypropane + HS-CoM. (2) (S)-2-hydroxypropyl-CoM = (S)-1,2-epoxypropane + HS-CoM. |
