2-methylbutanoate polyketide synthase EC#: 2.3.1.244; ChemWhat Code: 1377073

Product Name 2-methylbutanoate polyketide synthase
Example Structure Example Structure of 2-methylbutanoate polyketide synthase EC#: 2.3.1.244
Synonyms LDKS, LocF, lovastatin diketide synthase, LovF
EC Number 2.3.1.244
CAS Registry Number
Comments This polyketide synthase enzyme forms the (S)-2-methylbutanoate side chain during lovastatin biosynthesis by the filamentous fungus Aspergillus terreus. The overall reaction comprises a single condensation reaction followed by ¦Á-methylation, ¦Â-ketoreduction, dehydration, and ¦Á,¦Â enoyl reduction.
Cofactor
History
Reactions 2 malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 Nadph + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + 2 CO(2) + 2 NADP(+) + S-adenosyl-L- homocysteine + H(2)O.

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