| Product Name |
2-methylcitrate dehydratase |
| Example Structure |
 |
| Synonyms |
2-MC dehydratase, 2-methylcitrate dehydratase, 2-methylcitrate dehydratase 1, 2-Methylcitrate hydro-lyase, Dehydratase, 2-methylcitrate, methylcitrate dehydratase, mmgE, PrpD, SePrpD, STM0370 |
| EC Number |
4.2.1.79 |
| CAS Registry Number |
80891-26-5 |
| Comments |
The enzyme is specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)-methylcitrate [2]. The enzyme can also use?cis-aconitate as a substrate but more slowly [2]. Both this enzyme and EC?4.2.1.3, aconitate hydratase, are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate [2]. |
| Cofactor |
|
| History |
|
| Reactions |
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3- tricarboxylate + H(2)O. |
