2-oxo-acid reductase EC#: 1.1.99.30; ChemWhat Code: 1373706

Product Name 2-oxo-acid reductase
Example Structure Example Structure of 2-oxo-acid reductase EC#: 1.1.99.30
Synonyms (2R)-hydroxycarboxlate viologen oxidoreductase, (2R)-hydroxycarboxlate-viologen-oxidoreductase, (2R)-hydroxycarboxylate-viologen-oxidoreductase, 2-oxoacid reductase, D-2-hydroxy acid dehydrogenase, dehydrogenase, D-2-hydroxy acid, HVOR, hydroxy carboxylate viologen oxidoreductase, hydroxycarboxlate-oxidoreductase, hydroxycarboxlate-viologen-oxidoreductase
EC Number 1.1.99.30
CAS Registry Number
Comments Contains [4Fe-4S] and a mononucleotide molybdenum (pyranopterin) cofactor. Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates. Branching in a substrate at the C-3 position results in loss of activity. The enzyme from Proteus sp. is inactivated by oxygen.
Cofactor iron-sulfur;Mo-molybdopterin
History
Reactions A (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor.

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