Contains thiamine diphosphate and [4Fe-4S] clusters [2]. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For example, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).
Cofactor
iron-sulfur;thiamine diphosphate
History
Reactions
A 2-oxocarboxylate + CoA + 2 oxidized ferredoxin = an acyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
