| Product Name |
2-oxoglutarate carboxylase |
| Example Structure |
 |
| Synonyms |
carboxylating factor for ICDH, CFI, OGC, oxalosuccinate synthetase |
| EC Number |
6.4.1.7 |
| CAS Registry Number |
|
| Comments |
A biotin-containing enzyme that requires Mg2+?for activity. It was originally thought [1] that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC?1.1.1.41, isocitrate dehydrogenase (NAD+), but this has since been disproved [2]. The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC?1.1.1.41?[2]. |
| Cofactor |
Mg2+
biotin |
| History |
|
| Reactions |
Atp + 2-oxoglutarate + HCO(3)(-) = adp + phosphate + oxalosuccinate. |
