2-oxoglutarate synthase EC#: 1.2.7.3; ChemWhat Code: 1373907

Product Name 2-oxoglutarate synthase
Example Structure Example Structure of 2-oxoglutarate synthase EC#: 1.2.7.3
Synonyms 2-ketoglutarate ferredoxin oxidoreductase, 2-oxoglutarate ferredoxin oxidoreductase, 2-oxoglutarate oxidoreductase, 2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating), 2-oxoglutarate:ferredoxin oxidoreductase, alpha-ketoglutarate oxidoreductase, alpha-ketoglutarate synthase, alpha-ketoglutarate-ferredoxin oxidoreductase, CoA-dependent 2-ketoglutarate oxidoreductase, FOR enzyme, For(OGOR), forDABGE, KGOR, KOR enzyme, Kor(OGOR), OGOR, OOR, oorDABC
EC Number 1.2.7.3
CAS Registry Number 37251-05-1
Comments The enzyme contains thiamine diphosphate and 2 [4Fe-4S] clusters. Highly specific for 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).
Cofactor iron-sulfur;thiamine diphosphate
History
Reactions 2-oxoglutarate + CoA + 2 oxidized ferredoxin = succinyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).

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