2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase EC#: 2.4.99.20; ChemWhat Code: 1377867

Product Name 2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase
Example Structure Example Structure of 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase EC#: 2.4.99.20
Synonyms 2′-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, BST1, CD38, diphosphopyridine nucleosidase
EC Number 2.4.99.20
CAS Registry Number
Comments This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2′-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
Cofactor
History
Reactions NADP(+) + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.

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