2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase EC#: 1.3.7.11; ChemWhat Code: 1374151

Product Name 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase
Example Structure Example Structure of 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase EC#: 1.3.7.11
Synonyms AF0464, CrtI homologue, digeranylgeranylglycerophospholipid reductase, geranylgeranyl reductase, GGR, MA1484, MA1492, MA_1484, MA_1492, phytoene dehydrogenase family protein, Sa-GGR, SaGGR, Ta0516
EC Number 1.3.7.11
CAS Registry Number
Comments A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity. Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin [4].
Cofactor FAD
History
Reactions A 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster = a 2,3-bis-(O-geranylgeranyl)-sn-glycero- phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H(+).

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