23S rRNA (guanine748-N1)-methyltransferase EC#: 2.1.1.188; ChemWhat Code: 1376409
| Product Name | 23S rRNA (guanine748-N1)-methyltransferase |
| Example Structure |  |
| Synonyms | methyltransferase RlmAII, RlmA II, RlmA(II), RlmAII, rRNA large subunit methyltransferase II, TlrB, tylosin resistance methyltransferase RlmA(II), tylosin-resistance methyltransferase RlmA(II) |
| EC Number | 2.1.1.188 |
| CAS Registry Number | |
| Comments | The enzyme specifically methylates guanine748 at N1 in 23S rRNA. The methyltransferase RlmAII confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae [1]. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl-L-methionine + guanine(748) in 23S rRNA = S-adenosyl-L- homocysteine + N(1)-methylguanine(748) in 23S rRNA. |
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