24-hydroxycholesterol 7alpha-hydroxylase EC#: 1.14.14.26; ChemWhat Code: 1375533

Product Name 24-hydroxycholesterol 7alpha-hydroxylase
Example Structure Example Structure of 24-hydroxycholesterol 7alpha-hydroxylase EC#: 1.14.14.26
Synonyms 24-hydroxycholesterol 7alpha-monooxygenase, Cyp39a1, CYP39A1 oxysterol 7alpha-hydroxylase, oxysterol 7alpha-hydroxylase CYP39A1
EC Number 1.14.14.26
CAS Registry Number
Comments A P450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3¦Â,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH¡ªhemoprotein reductase.
Cofactor heme-thiolate
History
Reactions (24S)-cholest-5-ene-3-beta,24-diol + [reduced NADPH–hemoprotein reductase] + O(2) = (24S)-cholest-5-ene-3-beta,7-alpha,24-triol + [oxidized NADPH–hemoprotein reductase] + H(2)O.

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