| Product Name |
24-hydroxycholesterol 7alpha-hydroxylase |
| Example Structure |
 |
| Synonyms |
24-hydroxycholesterol 7alpha-monooxygenase, Cyp39a1, CYP39A1 oxysterol 7alpha-hydroxylase, oxysterol 7alpha-hydroxylase CYP39A1 |
| EC Number |
1.14.14.26 |
| CAS Registry Number |
|
| Comments |
A P450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3¦Â,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH¡ªhemoprotein reductase. |
| Cofactor |
heme-thiolate |
| History |
|
| Reactions |
(24S)-cholest-5-ene-3-beta,24-diol + [reduced NADPH–hemoprotein reductase] + O(2) = (24S)-cholest-5-ene-3-beta,7-alpha,24-triol + [oxidized NADPH–hemoprotein reductase] + H(2)O. |
