2,7,4′-trihydroxyisoflavanone 4′-O-methyltransferase EC#: 2.1.1.212; ChemWhat Code: 1376448

Product Name 2,7,4′-trihydroxyisoflavanone 4′-O-methyltransferase
Example Structure Example Structure of 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase EC#: 2.1.1.212
Synonyms 2-hydroxyisoflavanone 4′-O-methyltransferase, HI4’OMT, HI4’OMT/HM3OMT, HMM1, MtIOMT5, S-adenosyl-L-methionine: 2-hydroxyisoflavanone 4′-O-methyltransferase, SAM: 2,7,4′-trihydroxyisoflavanone 4′-O-methyltransferase, SAM:2,7,4′-trihydroxyisoflavanone 4′-O-methyltransferase
EC Number 2.1.1.212
CAS Registry Number
Comments Specifically methylates 2,4′,7-trihydroxyisoflavanone on the 4′-position. No activity with isoflavones [2]. The enzyme is involved in formononetin biosynthesis in legumes [1]. The protein from pea (Pisum sativum) also methylates (+)-6a-hydroxymaackiain at the 3-position (cf. EC 2.1.1.270, (+)-6a-hydroxymaackiain 3-O-methyltransferase) [4].
Cofactor
History
Reactions S-adenosyl-L-methionine + 2,4′,7-trihydroxyisoflavanone = S-adenosyl-L- homocysteine + 2,7-dihydroxy-4′-methoxyisoflavanone.

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