27S pre-rRNA (guanosine2922-2′-O)-methyltransferase EC#: 2.1.1.167; ChemWhat Code: 1376372
| Product Name | 27S pre-rRNA (guanosine2922-2′-O)-methyltransferase |
| Example Structure |  |
| Synonyms | Spb1p |
| EC Number | 2.1.1.167 |
| CAS Registry Number | |
| Comments | Spb1p is a site-specific 2′-O-ribose RNA methyltransferase that catalyses the formation of 2′-O-methylguanosine2922, a universally conserved position of the catalytic center of the ribosome that is essential for translation. 2′-O-Methylguanosine2922 is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA. In absence of snR52, Spb1p can also catalyse the formation of uridine2921 [1]. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl-L-methionine + guanosine(2922) in 27S pre-rRNA = S-adenosyl-L- homocysteine + 2′-O-methylguanosine(2922) in 27S pre-rRNA. |
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