| Product Name |
3-hydroxy-4-methylanthranilate adenylyltransferase |
| Example Structure |
 |
| Synonyms |
4-MHA activating enzyme, 4-MHA pentapeptide lactone synthase AcmA, 4-MHA-activating enzyme, AcmA, ACMS I, ACMSI, actinomycin synthase I, actinomycin synthetase I, sibE |
| EC Number |
2.7.7.97 |
| CAS Registry Number |
|
| Comments |
The enzyme, characterized from the bacteria?Streptomyces anulatus?and?Streptosporangium sibiricum, activates 3-hydroxy-4-methylanthranilate, a precursor of actinomycin antibiotics and the antitumor antibiotic sibiromycin, to an adenylate form, so it can be loaded onto a dedicated aryl-carrier protein. |
| Cofactor |
|
| History |
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| Reactions |
Atp + 3-hydroxy-4-methylanthranilate = diphosphate + 3-hydroxy-4- methylanthranilyl-adenylate. |
