3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase EC#: 1.14.14.12; ChemWhat Code: 1375510

Product Name 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
Example Structure Example Structure of 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase EC#: 1.14.14.12
Synonyms 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase, HsaAB
EC Number 1.14.14.12
CAS Registry Number
Comments This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone. It can use either FADH or FMNH2 as flavin cofactor. The enzyme forms a two-component system with a reductase (HsaB) that utilizes NADH to reduce the flavin, which is then transferred to the oxygenase subunit.
Cofactor
History
Reactions 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH(2) + O(2) = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + Fmn + H(2)O.

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