3-hydroxy acid dehydrogenase EC#: 1.1.1.381; ChemWhat Code: 1373506
| Product Name | 3-hydroxy acid dehydrogenase |
| Example Structure |  |
| Synonyms | |
| EC Number | 1.1.1.381 |
| CAS Registry Number | |
| Comments | The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from E. coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase). |
| Cofactor | |
| History | |
| Reactions | L-allo-threonine + NADP(+) = aminoacetone + CO(2) + Nadph. |
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