| Synonyms |
3-ketosteroid 9-alpha-hydroxylase, 3-ketosteroid 9alpha-hydroxylase, 3-ketosteroid-9alpha-hydroxylase, A5N73_13410, androsta-1,4-diene-3,17-dione, NADH:oxygen oxidoreductase (9alpha-hydroxylating), KSH, KshA, KshA1, KshA2, KshA3, KshA4, KshA5, KshAB, KshAMt, KshB, MN-kshA, Rv3526 |
| Comments |
The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It forms a two-component system with a ferredoxin reductase (KshB). The enzyme contains a Rieske-type iron-sulfur center and non-heme iron. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione. Formerly EC 1.14.13.142. |
