4′-demethylrebeccamycin synthase EC#: 4.3.3.5; ChemWhat Code: 1382885

Product Name 4′-demethylrebeccamycin synthase
Example Structure Example Structure of 4'-demethylrebeccamycin synthase EC#: 4.3.3.5
Synonyms ngt, RebG
EC Number 4.3.3.5
CAS Registry Number
Comments This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium?Lechevalieria aerocolonigenes. The enzyme is a glycosylase, and acts in the reverse direction to that shown. It has a wide substrate range, and was shown to glycosylate several substrates, including the staurosporine aglycone, EJG-III-108A, J-104303, 6-N-methyl-arcyriaflavin C and indolo-[2,3-a]-carbazole [1,2].
Cofactor
History
Reactions 4′-O-demethylrebeccamycin + H(2)O = dichloro-arcyriaflavin A + beta-D- glucose.

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