4-hydroxybutanoyl-CoA dehydratase EC#: 4.2.1.120; ChemWhat Code: 1382422

Product Name 4-hydroxybutanoyl-CoA dehydratase
Example Structure Example Structure of 4-hydroxybutanoyl-CoA dehydratase EC#: 4.2.1.120
Synonyms 4-hydroxybutyryl-CoA dehydratase, 4-hydroxybutyryl-coenzyme A dehydratase, 4HBD, AbfD, Igni_0595, Msed_1321, Tneu_0422
EC Number 4.2.1.120
CAS Registry Number
Comments Contains FAD and a [4Fe-4S] iron-sulfur cluster. The enzyme has been characterized from several microorganisms, including?Clostridium kluyveri, where it participates in succinate fermentation [1,2],?Clostridium aminobutyricum, where it participates in 4-aminobutyrate degradation [3,4], and?Metallosphaera sedula, where it participates in the 3-hydroxypropionate/4-hydroxybutyrate cycle, an autotrophic CO2?fixation pathway found in some thermoacidophilic archaea [5].
Cofactor iron-sulfur FAD
History
Reactions 4-hydroxybutanoyl-CoA = (E)-but-2-enoyl-CoA + H(2)O.

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