| Product Name |
4-hydroxybutyrate dehydrogenase |
| Example Structure |
 |
| Synonyms |
4HBD, gamma-hydroxybutyrate dehydrogenase, GHBDH, PGN 0724 protein, succinate semialdehyde reductase, uncharacterized oxidoreductase YihU, yihU |
| EC Number |
1.1.1.61 |
| CAS Registry Number |
9028-60-8 |
| Comments |
The enzyme oxidizes or reduces the hydroxy/keto group on C17 of estrogens and androgens in mammals and regulates the biological potency of these steroids. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.270, 3¦Â-hydroxysteroid 3-dehydrogenase [3]. The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, 20¦Á-hydroxysteroid dehydrogenase, it is Si-specific with respect to NAD(P)+. |
| Cofactor |
|
| History |
|
| Reactions |
4-hydroxybutanoate + NAD(+) = succinate semialdehyde + Nadh. |
