4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase EC#: 1.14.18.6; ChemWhat Code: 1375754

Product Name 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase
Example Structure Example Structure of 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase EC#: 1.14.18.6
Synonyms FA2H, AtFAH1, FA2H, FAH1, fatty acid 2-hydroxylase, fatty acid 2-hydroxylase 1, fatty acid alpha-hydroxylase, SCS7, Scs7p, scScs7p, sphingolipid alpha-hydroxylase
EC Number 1.14.18.6
CAS Registry Number
Comments The enzyme, characterized from yeast and mammals, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to (4R)-4-hydroxysphinganine during de novo ceramide synthesis. The enzymes from yeast and from mammals contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.7, dihydroceramide fatty acyl 2-hydroxylase.
Cofactor
History
Reactions A phytoceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (2’R)- 2′-hydroxyphytoceramide + 2 ferricytochrome b5 + H(2)O.

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