4-phosphoerythronate dehydrogenase EC#: 1.1.1.290; ChemWhat Code: 1373392

Product Name 4-phosphoerythronate dehydrogenase
Example Structure Example Structure of 4-phosphoerythronate dehydrogenase EC#: 1.1.1.290
Synonyms 4-O-phosphoerythronate dehydrogenase, D-erythronate-4-phosphate dehydrogenase, erythronate-4-phosphate dehydrogenase, More, pdx gene product, PDXB, PdxB 4PE dehydrogenase, RdxB
EC Number 1.1.1.290
CAS Registry Number
Comments This enzyme catalyses a step in a bacterial pathway for the biosynthesis of pyridoxal 5′-phosphate. The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD+. In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyses the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)-hydroxy acid [6]. cf. EC 1.1.1.399, 2-oxoglutarate reductase.
Cofactor NAD+
History
Reactions 4-phospho-D-erythronate + NAD(+) = (3R)-3-hydroxy-2-oxo-4- phosphonooxybutanoate + Nadh.

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