| Synonyms |
4,4-dimethyl-sterol 4alpha-methyl-oxidase, 4,4-dimethyl-zymosterol 4alpha-methyl-oxidase, 4-methyl sterol oxidase, 4-methylsterol oxidase, C-4 methyl sterol oxidase, C-4 sterol methyl oxidase, EC 1.14.99.16, ERG25, ERG25p, GintSMO protein, methyl sterol oxidase, methylsterol hydroxylase, methylsterol monooxygenase, NAD(P)H-dependent methylsterol oxidase, SC4MOL, SMO, sterol C-4 methyloxidase, sterol C4 methyl oxidase, sterol-C4-methyl oxidase, sterol-C4-methyl-oxidase |
| Comments |
This enzyme is found in fungi and animals and catalyses a step in the biosynthesis of important sterol molecules such as ergosterol and cholesterol, respectively. The enzyme acts on the 4¦Á-methyl group. Subsequent decarboxylation by EC 1.1.1.170, 3¦Â-hydroxysteroid-4¦Á-carboxylate 3-dehydrogenase (decarboxylating), occurs concomitantly with epimerization of the remaining 4¦Â-methyl into the 4¦Á position, thus making it a suitable substrate for a second round of catalysis. cf. EC 1.14.13.246, 4¦Â-methylsterol monooxygenase, EC 1.14.18.10, plant 4,4-dimethylsterol C-4¦Á-methyl-monooxygenase and EC 1.14.18.11, plant 4¦Á-monomethylsterol monooxygenase. Formerly EC 1.14.13.72 and EC 1.14.99.16. |
