The enzyme, characterized from the bacterium?Escherichia coli, shows strict specificity towards deoxyribonucleoside 5′-monophosphates and does not dephosphorylate 5′-ribonucleotides or ribonucleoside 3′-monophosphates. A divalent metal cation is required for activity, with cobalt providing the highest activity.
Cofactor
cobalt cation
History
Reactions
A 2′-deoxyribonucleoside 5′-monophosphate + H(2)O = a 2′-deoxyribonucleoside + phosphate.
