5′-(N7-methyl 5′-triphosphoguanosine)-[mRNA] diphosphatase EC#: 3.6.1.59; ChemWhat Code: 1381627

Product Name 5′-(N7-methyl 5′-triphosphoguanosine)-[mRNA] diphosphatase
Example Structure Example Structure of 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase EC#: 3.6.1.59
Synonyms Dcps, Dcs1, m7GpppN m7GMP phosphohydrolase, m7GpppX pyrophosphatase, yDcps, YLR270W
EC Number 3.6.1.59
CAS Registry Number
Comments The enzyme removes (decaps) the?N7-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides [3,6]. Decapping is an important process in the control of eukaryotic mRNA degradation. The enzyme functions to clear the cell of cap structure following decay of the RNA body [2]. The nematode enzyme can also decap triply methylated substrates, 5′-(N2,N2,N7-trimethyl 5′-triphosphoguanosine)-[mRNA] [4].
Cofactor
History
Reactions A 5′-(N(7)-methyl 5′-triphosphoguanosine)-[mRNA] + H(2)O = N(7)- methylguanosine 5′-phosphate + a 5′-diphospho-[mRNA].

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