5′-(N7-methylguanosine 5′-triphospho)-[mRNA] hydrolase EC#: 3.6.1.62; ChemWhat Code: 1381633

Product Name 5′-(N7-methylguanosine 5′-triphospho)-[mRNA] hydrolase
Example Structure Example Structure of 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase EC#: 3.6.1.62
Synonyms D10 decapping enzyme, D10 protein, D9 protein, Dcp2, decapping nudix hydrolase, H29K, hDcp2, hNUDT16, Nudt16, X29, X29 protein
EC Number 3.6.1.62
CAS Registry Number
Comments Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) [3]. The enzyme from?Vaccinia?virus is synergistically activated in the presence of Mg2+?and Mn2+?[5].
Cofactor
History
Reactions 5′-(N(7)-methylguanosine 5′-triphospho)-[mRNA] + H(2)O = N(7)- methylguanosine 5′-diphosphate + 5′-phospho-[mRNA].

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