5′-(N7-methylguanosine 5′-triphospho)-[mRNA] hydrolase EC#: 3.6.1.62; ChemWhat Code: 1381633
| Product Name | 5′-(N7-methylguanosine 5′-triphospho)-[mRNA] hydrolase |
| Example Structure | ![Example Structure of 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase EC#: 3.6.1.62](/wp-content/uploads/enzyme-structure/3.6.1.62.jpg) |
| Synonyms | D10 decapping enzyme, D10 protein, D9 protein, Dcp2, decapping nudix hydrolase, H29K, hDcp2, hNUDT16, Nudt16, X29, X29 protein |
| EC Number | 3.6.1.62 |
| CAS Registry Number | |
| Comments | Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) [3]. The enzyme from?Vaccinia?virus is synergistically activated in the presence of Mg2+?and Mn2+?[5]. |
| Cofactor | |
| History | |
| Reactions | 5′-(N(7)-methylguanosine 5′-triphospho)-[mRNA] + H(2)O = N(7)- methylguanosine 5′-diphosphate + 5′-phospho-[mRNA]. |
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