5,6-dimethylbenzimidazole synthase EC#: 1.13.11.79; ChemWhat Code: 1375014
| Product Name | 5,6-dimethylbenzimidazole synthase |
| Example Structure |  |
| Synonyms | BluB, bluB/cobT2, DMB-synthase |
| EC Number | 1.13.11.79 |
| CAS Registry Number | |
| Comments | The enzyme catalyses a complex oxygen-dependent conversion of reduced flavin mononucleotide to form 5,6-dimethylbenzimidazole, the lower ligand of vitamin B12. This conversion involves many sequential steps in two distinct stages, and an alloxan intermediate that acts as a proton donor, a proton acceptor, and a hydride acceptor [4]. The C-2 of 5,6-dimethylbenzimidazole is derived from C-1′ of the ribityl group of FMNH2 and 2-H from the ribityl 1′-pro-S hydrogen. While D-erythrose 4-phosphate has been shown to be one of the byproducts, the nature of the other product(s) has not been verified yet. |
| Cofactor | |
| History | |
| Reactions | FMNH(2) + Nadh + O(2) = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD(+) + other product(s). |
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