5a,11a-dehydrotetracycline 5-monooxygenase EC#: 1.14.13.234; ChemWhat Code: 1375479
| Product Name | 5a,11a-dehydrotetracycline 5-monooxygenase |
| Example Structure |  |
| Synonyms | 12-dehydrotetracycline 5-monooxygenase, anhydrotetracycline oxygenase, OtcC, oxyS |
| EC Number | 1.14.13.234 |
| CAS Registry Number | |
| Comments | The enzyme, characterized from the bacterium Streptomyces rimosus, is bifunctional, catalysing two successive monooxygenation reactions. It starts by catalysing the stereospecific hydroxylation of anhydrotetracycline at C6 (EC 1.14.13.38). If the released product is captured by EC 1.3.98.4, 12-dehydrotetracycline dehydrogenase (OxyR), it is reduced to tetracycline. However, if the released product is recaptured by OxyS, it performs an additional hydroxylation at C5, producing 5a,11a-dehydrooxytetracycline, which, following the action of OxyR, becomes oxytetracycline. |
| Cofactor | |
| History | |
| Reactions | 12-dehydrotetracycline + Nadph + O(2) = 5a,11a-dehydrooxytetracycline + NADP(+) + H(2)O. |
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