5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase EC#: 1.14.14.139; ChemWhat Code: 1375647
| Product Name | 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase |
| Example Structure |  |
| Synonyms | 12-alpha-hydroxylase, 12alpha-hydroxylase CYP8B1, 12alpha-hydroxylase gene, 5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase, CYP8B1, cytochrome P-450 LM4, cytochrome P450 8B1, More, sterol 12alpha hydroxylase, sterol 12alpha-hydroxylase, sterol 12alpha-hydroxylase CYP8B1, sterol 12alpha-hydroxylase/CYP8b1 |
| EC Number | 1.14.14.139 |
| CAS Registry Number | |
| Comments | A cytochrome P450 (heme-thiolate) protein found in mammals. This is the key enzyme in the biosynthesis of the bile acid cholic acid (3¦Á,7¦Á,12¦Á-trihydroxy-5¦Â-cholanoic acid). The activity of this enzyme determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid [3]. The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent [1]. |
| Cofactor | heme-thiolate |
| History | |
| Reactions |
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