(5R)-carbapenem-3-carboxylate synthase EC#: 1.14.20.3; ChemWhat Code: 1375845
| Product Name | (5R)-carbapenem-3-carboxylate synthase |
| Example Structure |  |
| Synonyms | carbapenem synthase, CarC |
| EC Number | 1.14.20.3 |
| CAS Registry Number | |
| Comments | Requires Fe2+. The enzyme is involved in the biosynthesis of the carbapenem ¦Â-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. It catalyses a stereoinversion at C5 and introduces a double bond between C-2 and C-3. |
| Cofactor | Fe2+ |
| History | |
| Reactions | (3S,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O(2) = (5R)-carbapen- 2-em-3-carboxylate + succinate + CO(2) + H(2)O. |
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