6-methylpretetramide 4-monooxygenase EC#: 1.14.13.232; ChemWhat Code: 1375477

Product Name 6-methylpretetramide 4-monooxygenase
Example Structure Example Structure of 6-methylpretetramide 4-monooxygenase EC#: 1.14.13.232
Synonyms OxyE, oxyL
EC Number 1.14.13.232
CAS Registry Number
Comments The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. That bacterium possesses two enzymes that can catalyse the reaction – OxyE is the main isozyme, while OxyL has a lower activity. OxyL is bifunctional, and its main function is EC 1.14.13.233, 4-hydroxy-6-methylpretetramide 12a-monooxygenase. Contains FAD.
Cofactor FAD
History
Reactions 6-methylpretetramide + Nadph + O(2) = 4-hydroxy-6-methylpretetramide + NADP(+) + H(2)O.

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