6-methylpretetramide 4-monooxygenase EC#: 1.14.13.232; ChemWhat Code: 1375477
| Product Name | 6-methylpretetramide 4-monooxygenase |
| Example Structure |  |
| Synonyms | OxyE, oxyL |
| EC Number | 1.14.13.232 |
| CAS Registry Number | |
| Comments | The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. That bacterium possesses two enzymes that can catalyse the reaction – OxyE is the main isozyme, while OxyL has a lower activity. OxyL is bifunctional, and its main function is EC 1.14.13.233, 4-hydroxy-6-methylpretetramide 12a-monooxygenase. Contains FAD. |
| Cofactor | FAD |
| History | |
| Reactions | 6-methylpretetramide + Nadph + O(2) = 4-hydroxy-6-methylpretetramide + NADP(+) + H(2)O. |
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