6-pyruvoyltetrahydropterin synthase EC#: 4.2.3.12; ChemWhat Code: 1382558

Product Name 6-pyruvoyltetrahydropterin synthase
Example Structure Example Structure of 6-pyruvoyltetrahydropterin synthase EC#: 4.2.3.12
Synonyms 2-amino-4-oxo-6-(erythro-1′,2′,3′-trihydroxypropyl)-7,8-dihydroxypterdine triphosphate lyase, 6-(1,2-dioxopropyl)tetrahydropterin synthase, 6-carboxy-5,6,7,8-tetrahydropterin synthase, 6-pyruvoyl tetrahydrobiopterin synthase, 6-pyruvoyl-tetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase paralog, 6-pyruvoyltetrahydropterin synthase [16-cysteine] (human clone lamda HSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase [25-glutamine] (human clone lambdaHSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase [de-57-valine] (human clone lambdaHSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase-like protein, EC 4.6.1.10, ePTPS, PH0634, PPH4 synthase, PPH4S, protein purple, PTP synthase, PTPS, PTPS homologue, PTPS-III, PTS, pyruvoyltetrahydropterin synthase, SCO 6650, synthase, 6-pyruvoyltetrahydropterin, synthase, 6-pyruvoyltetrahydropterin [16-cysteine] (human clone lamda HSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [25-glutamine] (human clone lamdaHSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [87-leucine] (human clone lamdaHSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [de-57-valine] (human clone lambdaHSY2 gene PCBD subunit)
EC Number 4.2.3.12
CAS Registry Number
Comments Catalyses triphosphate elimination and an intramolecular redox reaction in the presence of Mg2+. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC?1.1.1.153?(sepiapterin reductase) and EC?3.5.4.16?(GTP cyclohydrolase I) [3].
Cofactor Mg2+
History
Reactions 7,8-dihydroneopterin 3′-triphosphate = 6-pyruvoyl-5,6,7,8- tetrahydropterin + triphosphate.

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