| Product Name |
7-carboxy-7-deazaguanine synthase |
| Example Structure |
 |
| Synonyms |
7-carboxy-7-carbaguanine synthase, BsQueE, CDG synthase, queE, ToyC |
| EC Number |
4.3.99.3 |
| CAS Registry Number |
|
| Comments |
Requires Mg2+. The enzyme is a member of the superfamily of?S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable?S-adenosyl-L-methionine molecule. The?S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. The reaction is part of the biosynthesis pathway of queuosine. |
| Cofactor |
iron-sulfur
S-adenosyl-L-methionine
Mg2+ |
| History |
|
| Reactions |
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH(3). |
