7-carboxy-7-deazaguanine synthase EC#: 4.3.99.3; ChemWhat Code: 1382892

Product Name 7-carboxy-7-deazaguanine synthase
Example Structure Example Structure of 7-carboxy-7-deazaguanine synthase EC#: 4.3.99.3
Synonyms 7-carboxy-7-carbaguanine synthase, BsQueE, CDG synthase, queE, ToyC
EC Number 4.3.99.3
CAS Registry Number
Comments Requires Mg2+. The enzyme is a member of the superfamily of?S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable?S-adenosyl-L-methionine molecule. The?S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. The reaction is part of the biosynthesis pathway of queuosine.
Cofactor iron-sulfur S-adenosyl-L-methionine Mg2+
History
Reactions 6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH(3).

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