7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase EC#: 1.14.18.8; ChemWhat Code: 1375756

Product Name 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
Example Structure Example Structure of 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase EC#: 1.14.18.8
Synonyms 7alpha-hydroxy-4-cholest-3-on3 12alpha-monooxygenase, 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase, CYP12, CYP8B1, HCO 12alpha-hydroxylase, sterol 12alpha-hydroxylase
EC Number 1.14.18.8
CAS Registry Number
Comments A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH¡ªhemoprotein reductase and cytochrome b5 for maximal activity. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid [2].
Cofactor heme-thiolate
History
Reactions 7-alpha-hydroxycholest-4-en-3-one + 2 ferrocytochrome b5 + 2 H(+) + O(2) = 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + 2 ferricytochrome b5 + + H(2)O.

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