Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols. (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase).
Cofactor
History
Reactions
(1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin = S-adenosyl-L- homocysteine + an 8-methoxyfurocoumarin. (2) S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin.
