8-oxo-dGDP phosphatase EC#: 3.6.1.58; ChemWhat Code: 1381625
| Product Name | 8-oxo-dGDP phosphatase |
| Example Structure |  |
| Synonyms | MTH3, MutT homologue 3, NDX-1, NUDT, NUDT5 |
| EC Number | 3.6.1.58 |
| CAS Registry Number | |
| Comments | The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage. The preferred in vivo substrate is not known. The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC?3.6.1.55, 8-oxo-dGTP diphosphatase) [1,2]. Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolysed with broad specificity. The bifunctional enzyme NUDT5 also hydrolyses ADP-ribose to AMP and?D-ribose 5-phosphate (cf. EC?3.6.1.13, ADP-ribose diphosphatase) [4]. The human enzyme NUDT18 also hydrolyses 8-oxo-dADP and 2-hydroxy-dADP, the latter at a slower rate [6]. |
| Cofactor | |
| History | |
| Reactions | 8-oxo-dGDP + H(2)O = 8-oxo-dGMP + phosphate. |
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