8-oxo-dGTP diphosphatase EC#: 3.6.1.55; ChemWhat Code: 1381619
| Product Name | 8-oxo-dGTP diphosphatase |
| Example Structure |  |
| Synonyms | 7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase, 8-oxo-dGTP diphosphatase, AK369000, CiMutT, MTH1, MuT, MutT, MutT homologue 1, Nudix hydrolase, NUDT1, Nudx12 |
| EC Number | 3.6.1.55 |
| CAS Registry Number | |
| Comments | This enzyme hydrolyses the phosphoanhydride bond between the ¦Á and ¦Â phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. It does not hydrolyse 2-hydroxy-dATP (cf. EC?3.6.1.56, 2-hydroxy-dATP diphosphatase) [4]. Requires Mg2+. |
| Cofactor | Mg2+ |
| History | |
| Reactions | 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate. |
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