8-oxo-dGTP diphosphatase EC#: 3.6.1.55; ChemWhat Code: 1381619

Product Name 8-oxo-dGTP diphosphatase
Example Structure Example Structure of 8-oxo-dGTP diphosphatase EC#: 3.6.1.55
Synonyms 7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase, 8-oxo-dGTP diphosphatase, AK369000, CiMutT, MTH1, MuT, MutT, MutT homologue 1, Nudix hydrolase, NUDT1, Nudx12
EC Number 3.6.1.55
CAS Registry Number
Comments This enzyme hydrolyses the phosphoanhydride bond between the ¦Á and ¦Â phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. It does not hydrolyse 2-hydroxy-dATP (cf. EC?3.6.1.56, 2-hydroxy-dATP diphosphatase) [4]. Requires Mg2+.
Cofactor Mg2+
History
Reactions 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.

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