CyP-D is a part of the peptidyl-prolyl cis-trans isomerase (PPIase) family. CyP-D accelerates the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. CyP-D is key component of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.
Source
Escherichia coli.
Molecular Weight
Approximately 18.9 kDa, a single non-glycosylated polypeptide chain containing 178 amino acids.
Biological Activity
No data available
Appearance
Sterile colorless liquid.
Formulation
Supplied as a 0.2 um filtered solution in PBS, pH7.4, with 1 mM DTT, 10 % glycerol.
Endotoxin
Less than 0.1 EU/ug of rHuCyP-D as determined by LAL method.
Reconstitution
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 6 months from date of receipt, -20 to -70 °C as supplied.- 3 months, -20 to -70 °C under sterile conditions after opening.
